New Characters

Children of the Original Cast

 * Zac Efron is cast as James Lucas "Jamie" Scott, Nathan and Haley's oldest son
 * Taylor Lautner is cast as Charles "Chuck" Scolnik, Jamie's best friend.
 * Vanessa Hudgens is cast as Madison Landry, Jamie's girlfriend.
 * Matt Lanter is cast as Davis Baker, Jude's twin brother, Brooke and Julian's son
 * Dylan O'Brien is cast as Jude Baker, Davis' twin brother, Brooke and Julian's son
 * Aly Michalka is cast as Sawyer Scott, Lucas and Peyton's oldest daughter
 * Penn Badgley is cast as Logan Evans, Clay and Quinn's oldest son
 * Nina Dobrev is cast as Lily Roe Scott, Karen and Keith's daughter, Lucas' sister
 * Paul Wesley is cast as Nathan Smith, Tim and Bevin's son
 * Lily Collins is cast as Jennifer "Jenny" Jagielski, Jake's daughter
 * Sterling Sulieman is cast as Andre Fields, Jamie's friend from childhood
 * Carlson Young is cast as Brooke Keller, Chris' oldest daughter
 * Leven Rambin is cast as Lydia Scott, Nathan and Haley's oldest daughter
 * Logan Lerman is cast as Elliot McFadden, Mouth and Millie's oldest son
 * Selena Gomez is cast as Melissa Adams, Chase and Alex's daughter
 * Jessica Stroup is cast as Kelsey Evans, Hunter's twin sister, Clay and Quinn's oldest daughter
 * Chace Crawford is cast as Hunter Evans, Kelsey's twin brother, Clay and Quinn's younger son
 * Tom Maden is cast as Jackson "Jax" Scott, Nathan and Haley's 2nd son
 * Danielle Campbell is cast as Haley Baker, Matthew's twin sister, Brooke and Julian's oldest daughter
 * Colton Haynes is cast as Matthew Baker, Haley's twin brother, Brooke and Julian's youngest son
 * Willa Holland is cast as Eilzabeth Scott, Lucas and Peyton's 2nd daughter
 * Nick Robinson is cast as Keith Scott, Lucas and Peyton's oldest son
 * Marie Avgeropoulos is cast as Octavia Hargrove, Karen and Andy's daughter
 * Cody Christian is cast as Lucas McFadden, Mouth and Millie's second son
 * Chloe Moretz is cast as Taylor Scott, Jimmy's twin sister, Lucas and Peyton's youngest daughter
 * Ricardo Hoyos is cast as Milo Adams, Chase and Alex's son
 * Minka Kelly is cast as Sarah Evans, Vivian's twin, Clay and Quinn's 2nd daughter
 * Leighton Meester is cast as Vivian Evans, Sarah's twin, Clay and Quinn's youngest daughter
 * Zach Roerig is cast as Jeremy Jagielski, Jake's son
 * Candice Accola is cast as Katherine "Katie" Keller, Chris' younger daughter
 * Crystal Reed is cast as Grace McFadden, Melanie's twin, Mouth and Millie's daughter
 * Tammin Sursok is cast as Melanie McFadden, Grace's twin, Mouth and Millie's daughter
 * Keegan Allen is cast as Kieran Scott, Natalie's twin brother, Nathan and Haley's youngest son
 * Lucy Hale is cast as Natalie "Nina" Scott, Kieran's twin sister, Nathan and Haley's younger daughter
 * Grey Damon is cast as Chris Hargrove, Kevin's twin, Karen and Andy's older son
 * Ed Westwick is cast as Kevin Hargrove, Chris's twin, Karen and Andy's younger son
 * Tristan Wilds is cast as Andy Taylor, Lauren's twin brother, Skills and Bevin's son
 * Kat Graham is cast as Lauren Taylor, Andy's twin sister, Skills and Bevin's daughter
 * Matt Barr is cast as James "Jimmy" Scott, Taylor's twin brother, Lucas and Peyton's youngest son
 * Bella Thorne is cast as Serena Baker, Brooke and Julian's younger daughter